Peer-reviewed veterinary case report
Caveolin-1 protein is reduced in dog mammary tumors compared
By Zuccari, D A P C et al.·Published in Genetics and molecular research : GMR·2012·Laborató·View original on PubMed →
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Original publication title: Immunohistochemical and molecular analysis of caveolin-1 expression in canine mammary tumors.
- Species:
- dog
Plain-English summary
A study found that female dogs with mammary tumors often had lower levels of a protein called caveolin-1 (Cav-1) compared to normal mammary tissue. This protein is thought to help prevent tumor spread, and its reduced expression was linked to larger tumors and poorer outcomes. The research suggests that measuring Cav-1 levels could help predict how well a dog might do after being diagnosed with a mammary tumor. This information could be useful for veterinarians in determining treatment options and prognosis.
People also search for: dog mammary tumor treatment · canine cancer survival rates · caveolin-1 in dogs
Abstract
Caveolin-1 (Cav-1) is a structural protein present in invaginations of the cell membrane. In human breast cancer, the cav-1 gene is believed to be a tumor suppressor gene associated with inhibition of tumor metastasis. However, little is known about its expression, regulation and function in canine mammary tumors. Expression levels of cav-1 were investigated using real-time PCR and immunohistochemical detection with an anti-human Cav-1 antibody. Gene expression stability of different samples was analyzed using the geNorm software. Mammary tumors from 51 female dogs were compared to normal mammary tissue from 10 female dogs. Malignant mammary cells showed a loss of Cav-1 expression by quantitative RT-PCR and weak Cav-1 staining by immunohistochemistry compared to normal mammary gland tissue. There was a significant relationship between outcome and immunostaining as well as with tumor size, indicating that caveolin subexpression has a positive predictive value and is related to higher survival and smaller tumor size. Our findings indicate that Cav-1 is a potential prognostic marker for canine mammary tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22370882/