Peer-reviewed veterinary case report
IGF-I and IGF-II levels help diagnose malignant mammary tumors in dogs
By Ozmen, Ozlem·Published in Acta veterinaria Hungarica·2020·Department of Pathology·View original on PubMed →
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Original publication title: Immunohistochemical study of IGF-I and IGF-II expression in canine mammary tumours: Prognostic and diagnostic role.
- Species:
- dog
Plain-English summary
A study looked at mammary tumors in dogs, which are quite common, to see how certain growth factors (IGF-I and IGF-II) might help determine if a tumor is benign or malignant. Researchers found that benign tumors had low levels of these growth factors, while malignant tumors showed much higher levels, especially IGF-II. This suggests that measuring IGF-I and IGF-II could help veterinarians diagnose the severity of mammary tumors in dogs and might lead to new treatment options in the future.
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Abstract
Mammary tumours are among the most common tumours in dogs and are of interest due to their similarities to human breast tumours. Insulin-like growth factors (IGFs) are considered important in cell growth and development. The aim of this study was to investigate the immunohistochemical expression of IGF-I and IGF-II in benign and malignant canine mammary tumours. In this study, 10 benign and 10 malignant mammary tumours from the archives of the Department of Pathology were used, and five normal breast tissues were used as controls. It was observed that the expression of IGF-I and IGF-II was low to absent in benign tumours and increased in malignant tumours. The expression of IGF-II was higher than that of IGF-I. This study showed that IGF-I and IGF-II can be used as criteria for malignancy in canine mammary tumours. The results also indicate that IGF-I and IGF-II may be used as early diagnostic markers, and their inhibition may be used for the treatment of canine and human mammary tumours in the future.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33221734/