Peer-reviewed veterinary case report
How types of mammary cancer affect survival in female dogs
By Seung, Byung-Joon et al.·Published in Journal of comparative pathology·2021·Department of Veterinary Pathology, South Korea·View original on PubMed →
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Original publication title: Impact of Histological Subtype on Survival in Canine Mammary Carcinomas: a Retrospective Analysis of 155 Cases.
- Species:
- dog
Plain-English summary
A study looked at 155 female dogs with mammary tumors to understand how different types of these tumors affect survival. The research found that certain tumor types, like carcinosarcoma and anaplastic carcinoma, had the worst outcomes, while others, like comedocarcinoma, were also aggressive. Factors such as the dog's age and whether the tumor had spread to lymph nodes were important for predicting survival. This information can help veterinarians provide better prognoses and treatment plans for dogs diagnosed with mammary tumors.
People also search for: dog mammary tumor survival rates · canine mammary carcinoma treatment · female dog breast cancer prognosis
Abstract
Canine mammary carcinoma (CMC) is the most common type of neoplasm in intact female dogs. While a previous study in Western countries validated the 2011 classification as an independent prognostic indicator in CMC, its role in CMC prognostication in Asian countries such as Korea remains unclear. In the present study, we estimate the survival rates in CMC types defined by the 2011 classification, elucidate the prognostic significance of the histological subtype and grade and that of the lymphatic invasion status in CMC, and validate the 2011 classification as an independent prognostic indicator in a large cohort of CMCs (excluding cases of multicentric CMCs). A total of 155 CMC cases retrieved from archived formalin-fixed, paraffin-embedded tissues, along with 2-year follow-up data, were retrospectively analysed. A significant association was found between the histological subtype of the 2011 classification and the tumour-specific survival. Carcinosarcoma, adenosquamous carcinoma and anaplastic carcinoma subtypes were associated with the poorest prognosis. Dogs with comedocarcinoma and solid carcinoma followed a disease course that was more aggressive than that observed in dogs with a carcinoma arising in a benign mixed tumour. Moreover, age, histological grade and lymphatic invasion status significantly correlated with tumour-specific survival in univariate analysis. In multivariate analysis, histological subtype, age and lymphatic invasion status remained independent prognostic factors for CMC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34340801/