Peer-reviewed veterinary case report
Dogs with malignant mammary tumors and high HER-2 protein live longer
By Hsu, Wei-Li et al.·Published in Veterinary journal (London, England : 1997)·2009·Graduate Institute of Veterinary Public Health·View original on PubMed →
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Original publication title: Increased survival in dogs with malignant mammary tumours overexpressing HER-2 protein and detection of a silent single nucleotide polymorphism in the canine HER-2 gene.
- Species:
- dog
Plain-English summary
A study looked at dogs with malignant mammary tumors and found that those with higher levels of a protein called HER-2 had a better chance of surviving after surgery. Out of 91 dogs with these tumors, nearly 30% showed overexpression of HER-2. These dogs tended to live longer than those with normal levels of the protein. The researchers also identified a specific genetic change in some tumors, but it didn't affect the protein's function. This information could help vets predict outcomes for dogs with similar tumors and guide treatment options.
People also search for: dog mammary tumor survival rate · HER-2 protein in dogs · malignant mammary tumors treatment
Abstract
The aims of this study were to explore the relationship between clinical outcome and HER-2 protein expression in dogs with malignant mammary tumours after surgery and to determine the sequence of the HER-2 gene. Tissues from 91 dogs diagnosed with malignant mammary tumours, six with benign lesions and two normal mammary glands were analysed for the expression of HER-2 by immunohistochemistry (IHC). Exons 14-18 of the HER-2 gene were amplified by reverse transcriptase polymerase chain reaction and sequenced in 19 tumours with IHC scores >2+; larger coding regions of HER-2 were analysed in five tumours. HER-2 protein overexpression was found in 27/91 (29.7%) of canine malignant mammary tumours. Dogs with HER-2-overexpressing malignant mammary tumours tended to have a higher survival rate than those that expressed a normal level of HER-2 within 2 years of surgery. In 3/19 cases, HER-2 sequences had a single nucleotide polymorphism, T(1725)C, with no change in the amino acid identity (Cys). No other sequence aberration of HER-2 was found.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18061495/