Peer-reviewed veterinary case report
Euphorbia royleana extract helps treat dog mammary tumors better
By Huang, Yu-Ya et al.·Published in BMC veterinary research·2020·Department and Graduate Institute of Veterinary Medicine·View original on PubMed →
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Original publication title: Inhibiting autophagy potentiates the antitumor efficacy of Euphorbia royleana for canine mammary gland tumors.
- Species:
- dog
Plain-English summary
A study found that a plant called Euphorbia royleana may help treat mammary gland tumors in female dogs. Researchers tested this plant on tumor cells and found it could stop the growth of these cells and even shrink tumors in dogs. The treatment worked by causing the cancer cells to die through a process called apoptosis (cell death) and by stopping them from dividing. Importantly, the treatment showed low toxicity, meaning it was safe for the dogs. This suggests that Euphorbia royleana could be a promising option for treating mammary tumors in dogs.
People also search for: dog mammary tumor treatment · Euphorbia royleana for dog cancer · canine breast cancer natural remedies
Abstract
BACKGROUND: Canine mammary gland tumors (cMGTs) are the most common neoplasms in intact female canines and viewed as a suitable model for studying human breast cancers. Euphorbia royleana has been reported to have a variety of antitumor efficacies. We have prepared the crude extracts of E. royleana in ethanol and hexane solvents to evaluate the anti-tumor effects for cMGT in vitro and in vivo. RESULTS: The results showed that E. royleana could inhibit cell proliferation and colony formation in cMGT cells. The suppression of tumor cell growth resulted from necrosis and cell cycle arrest. Moreover, autophagy appears to play a critical role in E. royleana-mediated cell death by triggering cell apoptosis. The in vivo results also revealed that E. royleana treatment could reduce the size of solid tumors while exhibiting low toxicity in cMGT-bearing nude mice. CONCLUSIONS: The anti-tumor mechanisms of E. royleana were firstly verified to show it would cause autophagic cell death, apoptosis, and cell cycle arrest in canine mammary tumor cells. The in vitro and in vivo findings in the present study revealed E. royleana has potential anticancer effects for the treatment of canine mammary gland tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32532319/