Peer-reviewed veterinary case report
Inhibition of Soluble Epoxide Hydrolase Activity by Components of <i>Glycyrrhiza uralensis</i>.
- Year:
- 2023
- Authors:
- Kim JH et al.
- Affiliation:
- Department of Herbal Crop Research · South Korea
Abstract
Soluble epoxide hydrolase (sEH) is a target enzyme for the treatment of inflammation and cardiovascular disease. A <i>Glycyrrhiza uralensis</i> extract exhibited ~50% inhibition of sEH at 100 μg/mL, and column chromatography yielded compounds <b>1</b>-<b>11</b>. Inhibitors <b>1</b>, <b>4</b>-<b>6</b>, <b>9</b>, and <b>11</b> were non-competitive; inhibitors <b>3, 7</b>, <b>8</b>, and <b>10</b> were competitive. The IC<sub>50</sub> value of inhibitor <b>10</b> was below 2 μM. Molecular simulation was used to identify the sEH binding site. Glycycoumarin (<b>10</b>) requires further evaluation in cells and animals.
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Search related cases →Original publication: https://europepmc.org/article/MED/37047457