Peer-reviewed veterinary case report
New cell therapy shows promise for insulin-dependent diabetes in pet
By Gooch, Anna et al.·Published in PloS one·2019·SymbioCellTech, United States·View original on PubMed →
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Original publication title: Interim report on the effective intraperitoneal therapy of insulin-dependent diabetes mellitus in pet dogs using "Neo-Islets," aggregates of adipose stem and pancreatic islet cells (INAD 012-776).
- Species:
- dog
Plain-English summary
Four insulin-dependent diabetic dogs were treated with a new therapy called "Neo-Islets," which combines pancreatic islet cells with protective stem cells. After the treatment, these dogs showed significant improvements, including up to a 50% reduction in their daily insulin needs and lower blood sugar levels. Remarkably, the dogs did not experience any adverse reactions, and the Neo-Islets appeared to function well without the need for anti-rejection medications. This promising therapy could change how diabetes is managed in dogs, offering a less invasive option for better blood sugar control.
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Abstract
We previously reported that allogeneic, intraperitoneally administered "Neo-Islets," composed of cultured pancreatic islet cells co-aggregated with high numbers of immunoprotective and cytoprotective Adipose-derived Stem Cells, reestablished, through omental engraftment, redifferentiation and splenic and omental up-regulation of regulatory T-cells, normoglycemia in autoimmune Type-1 Diabetic Non-Obese Diabetic (NOD) mice without the use of immunosuppressive agents or encapsulation devices. Based on these observations, we are currently testing this Neo-Islet technology in an FDA guided pilot study (INAD 012-776) in insulin-dependent, spontaneously diabetic pet dogs by ultrasound-guided, intraperitoneal administration of 2x10e5 Neo-Islets/kilogram body weight to metabolically controlled (blood glucose, triglycerides, thyroid and adrenal functions) and sedated animals. We report here interim observations on the first 4 canine Neo-Islet-treated, insulin-dependent pet dogs that are now in the early to intermediate-term follow-up phase of the planned 3 year study (> 6 months post treatment). Current results from this translational study indicate that in dogs, Neo-Islets appear to engraft, redifferentiate and physiologically produce insulin, and are rejected by neither auto- nor allo-immune responses, as evidenced by (a) an absent IgG response to the allogeneic cells contained in the administered Neo-Islets, and (b) progressively improved glycemic control that achieves up to a 50% reduction in daily insulin needs paralleled by a statistically significant decrease in serum glucose concentrations. This is accomplished without the use of anti-rejection drugs or encapsulation devices. No adverse or serious adverse events related to the Neo-Islet administration have been observed to date. We conclude that this minimally invasive therapy has significant translational relevance to veterinary and clinical Type 1 diabetes mellitus by achieving complete and at this point partial glycemic control in two species, i.e., diabetic mice and dogs, respectively.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31536503/