Peer-reviewed veterinary case report
Dog with multiple skin lumps treated successfully with isotretinoin
By Toma, Stefano & Noli, Chiara·Published in Veterinary dermatology·2005·Ospedale Veterinario Cuneese, Italy·View original on PubMed →
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Original publication title: Isotretinoin in the treatment of multiple benign pilomatrixomas in a mixed-breed dog.
- Species:
- dog
Plain-English summary
An 18-month-old mixed-breed dog had multiple skin nodules that grew larger and more numerous over eight months. After a biopsy confirmed these were benign pilomatrixomas (a type of skin tumor), the dog was treated with isotretinoin, a medication that helped stabilize the size and number of the nodules. When the dosage was reduced, the nodules increased again, but the dog showed no side effects from the treatment. This case is notable as it's the first report of using isotretinoin successfully for this condition in a young dog.
People also search for: dog skin nodules treatment · pilomatrixoma in dogs · isotretinoin for dogs skin tumors
Abstract
An 18-month-old cross-breed dog developed multiple skin nodules, which over 8 months had increased in size and number. Biopsy samples were submitted for histopathological examination and revealed multiple benign pilomatrixomas. The dog was treated with 1 mg kg(-1) isotretinoin daily, which led to a stabilization of the size and number of the lesions. Attempts to lower the dosage to an every other day regimen led to an increase in the nodules' size and number. Monthly complete blood count and chemistry tests and Schirmer tear tests were performed to monitor any adverse effects of the retinoid treatment. No adverse effects were noted. To the authors' knowledge, this is the first report of multiple pilomatrixomas arising in a young dog and successfully controlled with oral retinoids.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16238816/