Peer-reviewed veterinary case report
Eye surface and tear changes in diabetic dogs
By Cullen, Cheryl L et al.·Published in Veterinary ophthalmology·2005·Department of Companion Animals, Canada·View original on PubMed →
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Original publication title: Keratoconjunctival effects of diabetes mellitus in dogs.
- Species:
- dog
Plain-English summary
A group of diabetic dogs with cataracts showed signs of eye problems, including lower tear production and sensitivity compared to non-diabetic dogs. Tests revealed that these diabetic dogs had higher glucose levels in their tears and less stable tear films, which can lead to discomfort and potential eye damage. While the degree of cataracts was similar across groups, the diabetic dogs had some changes in their conjunctival tissue. Managing diabetes and monitoring eye health is crucial for these pets to help maintain their comfort and vision.
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Abstract
OBJECTIVES: To compare Schirmer tear test (STT) values, corneal sensitivity, tear film break up times (TFBUTs), and tear glucose concentrations in relation to conjunctival microflora, and conjunctival cytologic and histologic findings among diabetic cataractous, nondiabetic cataractous, and nondiabetic noncataractous dogs. Procedures Fifteen dogs in each category underwent neuro-ophthalmic examination; aerobic, anaerobic and fungal conjunctival cultures; assessment of corneal touch threshold (CTT), STT, tear glucose, TFBUT; and conjunctival cytology and histology (in certain cases only). Degree of cataract and uveitis were critically graded. Glycemic control was estimated using serum fructosamine and glycosylated hemoglobin. RESULTS: STT values were significantly lower in diabetic cataractous than nondiabetic noncataractous dogs. CTT of diabetic cataractous dogs was significantly lower than that of nondiabetic noncataractous dogs. Mean TFBUTs were significantly less in diabetic cataractous dogs than nondiabetic cataractous and nondiabetic noncataractous dogs. Tear glucose concentrations were significantly higher in diabetic cataractous dogs than nondiabetic cataractous and nondiabetic noncataractous dogs. Conjunctival microbial isolates did not differ among groups. There were no significant differences in degree of cataract or uveitis between diabetic cataractous and nondiabetic cataractous groups. There was mild submucosal inflammatory infiltrate in conjunctival specimens from diabetic dogs. Conjunctival epithelial dysplasia and/or squamous metaplasia was/were detected in conjunctival biopsies of 5/7 diabetic dogs. Reductions in conjunctival goblet cell (GC) densities were noted in 4/7 diabetic dogs; there were no significant differences in mean GC densities among the three groups. CONCLUSIONS: Diabetic cataractous dogs have significantly altered keratoconjunctival characteristics compared to nondiabetic cataractous and nondiabetic noncataractous dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16008700/