Peer-reviewed veterinary case report
Amyloid buildup found in dog mammary tumors
By Taniyama, H et al.·Published in Veterinary pathology·2000·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Localized amyloidosis in canine mammary tumors.
- Species:
- dog
Plain-English summary
A 9-year-old female Dachshund was diagnosed with a mammary tumor and showed signs of localized amyloidosis, which is a buildup of abnormal protein. The tumor was identified as an adenocarcinoma, a type of cancer. During testing, the vet found amyloid deposits in the tumor tissue, which are linked to the dog's lactation. The findings indicated that the amyloid was related to the proteins produced during milk production. Treatment options for the tumor would typically include surgery and possibly chemotherapy, but the specific outcome for this dog wasn't detailed.
People also search for: dog mammary tumor treatment · Dachshund cancer symptoms · localized amyloidosis in dogs
Abstract
Histopathologic and immunohistochemical examinations were performed on localized amyloidosis associated with mammary tumors in two dogs. These tumors were identified as adenoma and adenocarcinoma. An acellular, amorphous pale eosinophilic material (amyloid) was observed in the lumina of acini lined by neoplastic cells and in the stroma of the tumors. Concentrically laminated pale eosinophilic bodies (corpora amylacea) were also found in the lumina of the acini. Amyloid and corpora amylacea stained positively with Congo red with and without 5% potassium permanganate pretreatment and revealed a green birefringence under polarized light. Corpora amylacea showed an occasional Maltese-cross pattern. Immunohistochemically, amyloid and corpora amylacea usually stained positively with anti-bovine alpha-casein antibody but negatively with anti-human amyloid AA, anti-bovine kappa-light and lambda-light chains, anti-human lactoferrin, anti-human transferrin, anti-human secretory component, and anti-human polyglucosan antibodies. These findings suggested that the amyloid deposition in these canine mammary tumors was related to lactating casein.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10643991/