Peer-reviewed veterinary case report
Long-term Outcome of a Chihuahua With Idiopathic Syndrome of Inappropriate Antidiuretic Hormone Secretion.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2024
- Authors:
- Adin, Darcy B et al.
- Affiliation:
- From the Department of Small Animal Clinical Sciences (D.B.A. · United States
- Species:
- dog
Plain-English summary
A 3-year-old female Chihuahua was brought to the vet because she was drinking and urinating a lot after being adopted. Tests showed that she had low levels of sodium and chloride in her blood, and her body was producing too much antidiuretic hormone, which helps control water balance. After ruling out other possible causes like kidney or adrenal problems, the vet diagnosed her with a condition called idiopathic syndrome of inappropriate antidiuretic hormone secretion, meaning the cause was unknown. Remarkably, two years later, she is doing well without any specific treatment, just needing a little extra salt in her diet. This case is notable because she showed no other health issues and had a good long-term outcome without needing more intensive treatment.
Abstract
An approximately 3 yr old female Chihuahua was presented for evaluation of polyuria and polydipsia noted by the owner after adoption. Serum biochemistry and urinalysis revealed hyponatremia, hypochloremia, hypo-osmolality, and normal fractional excretion of sodium. Serum antidiuretic hormone concentration was 5.54 pg/mL and serum copeptin concentration was 135.40 pg/mL. The antidiuretic hormone value was above the reported range for healthy dogs and was considered inappropriate in light of serum osmolality. Idiopathic syndrome of inappropriate antidiuretic hormone secretion was considered the most likely diagnosis after excluding other potential causes, such as diuretic use, renal disease, adrenal disease, and thyroid dysfunction. The dog remains clinically well 2 yr after diagnosis without specific treatment other than minimal dietary salt supplementation. This case is unique because of the absence of systemic or neurologic signs, good long-term outcome without treatment, and use of novel diagnostic testing.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39480739/