Peer-reviewed veterinary case report
Dog with mammary tumor showing rare sebaceous cell changes
By Yasuno, Kyohei et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2011·Research Institute of Biosciences, Japan·View original on PubMed →
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Original publication title: Mammary adenoma with sebaceous differentiation in a dog.
- Species:
- dog
Plain-English summary
A 13-year-old mixed-breed female dog had mammary tumors on her right side, which were found to be a type of tumor called a mammary adenoma. This tumor had some unusual features, including cells that looked like those found in sebaceous (oil) glands. The vet performed tests to understand the tumor better, and while the findings were complex, they confirmed the presence of these unique cells. The dog was likely treated based on the findings, but the specific treatment details were not mentioned.
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Abstract
The current report describes a complex canine mammary adenoma with a rare histological feature characterized by sebaceous differentiation of tumor cells. A 13-year-old, mixed-breed, intact female dog had mammary tumors on the right mammary chain. Histologically, one of the masses was composed of bilayered ductal structures with luminal epithelial cells together with basaloid or myoepithelial cell components. Within the tumor, there were a number of lobules and nests of large foamy cells associated with basaloid reserve-like cells similar to sebaceous gland. Squamous metaplasia was also seen within the tumor. Immunohistochemical staining indicated that the tumor cells with sebaceous differentiation were positive for cytokeratin (CK)14 and that the associated basaloid reserve-like cells were positive for p63. In contrast, other luminal epithelial tumor cells were positive for CK18 and CK19, but not for CK14 and p63. The myoepithelial cells were positive for α-smooth muscle actin and p63. The expression of p63 in both sebaceous basaloid reserve-like cells and myoepithelial cells, and their structural continuity within the tumor tissue, suggested a common origin of these 2 components.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21908334/