Peer-reviewed veterinary case report
Dog with mammary lipid-rich carcinoma and amyloid deposits in lymph
By Tei, Meina et al.·Published in The Journal of veterinary medical science·2012·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Mammary lipid-rich carcinoma with extensive amyloid deposition in a dog.
- Species:
- dog
Plain-English summary
A 6-year-old female Labrador retriever was brought to the vet with a noticeable mass in her right mammary gland and swollen lymph nodes in her groin and armpit. Tests indicated that she had a malignant tumor called a lipid-rich carcinoma, which produces fatty substances and was associated with amyloid deposits. The tumor was confirmed through a biopsy, showing unusual cells that were producing these deposits. Unfortunately, this type of cancer is serious, and the specific treatment options would depend on the overall health of the dog and the extent of the disease.
People also search for: dog mammary tumor treatment · Labrador retriever cancer symptoms · dog swollen lymph nodes causes
Abstract
A 6-year-old female Labrador retriever presented with a mass in the right mammary gland, and swollen right inguinal and axillary lymph nodes. Fine needle aspiration biopsy suggested a malignant lipid-producing tumor, such as liposarcoma. Histopathologically, the neoplasms were solid, lobulated nests of atypical epithelial cells with a large amount of extracellular deposits of amyloid in both mammary gland and lymph nodes. The proliferating cells contained large cytoplasmic vacuoles, positive for oil red-O. These cells were immunopositive for cytokeratin (AE1/AE3) and β-casein and negative for SMA. The amyloid deposits were immunopositive for β-casein. These findings suggested that the proliferating cells secreted β-casein forming amyloid deposits. This is the first report of mammary lipid-rich carcinoma with extensive amyloid deposition derived from β-casein.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22261147/