Peer-reviewed veterinary case report
Cat diagnosed with monoblastic leukemia and chronic basophilic
By Shimoda, Tetsuya et al.·Published in The Journal of veterinary medical science·2022·Sanyo Animal Medical Center, Japan·View original on PubMed →
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Original publication title: Monoblastic leukemia (M5a) with chronic basophilic leukemia in a cat.
- Species:
- cat
Plain-English summary
A cat was brought in showing signs of depression and not eating. Blood tests revealed severe anemia, low platelet counts, and a high number of white blood cells, indicating a serious condition. Further examination of the bone marrow showed an abnormal increase in specific types of white blood cells, leading to a diagnosis of acute monoblastic leukemia and chronic basophilic leukemia. Unfortunately, this condition is quite serious, and the treatment options may be limited.
People also search for: cat depression and not eating · cat leukemia symptoms · cat bone marrow disease treatment
Abstract
A cat was presented with depression and anorexia. The complete blood cell count (CBC) revealed non-regenerative anemia (PCV, 8.5%), marked thrombocytopenia (2,400/µl), and leukocytosis (32,090/µl). In the peripheral blood, proliferation of blast cells (85%; 27,276/µl) and basophils (7.7%; 2,460/µl) was observed. Bone marrow aspirate showed hyperplasia with 8.8% blasts and 90.2% basophils of all nucleated cells. The blast cells were negative for myeloperoxidase staining and positive for alpha-naphthol butyrate esterase staining, indicating the agranular blasts are monoblasts. Thus, acute monoblastic leukemia (M5a) with chronic basophilic leukemia was diagnosed. Basophils accounted for more than 40% of the bone marrow, and we diagnosed secondary basophilic leukemia. Secondary basophilic leukemia should be included in the differential list when abnormal basophil increases are observed in feline bone marrow.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34911870/