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Peer-reviewed veterinary case report

Spayed Toy Poodle with mammary gland cancer spreading to many organs

By Yi, Seung-Won et al.·Published in Journal of comparative pathology·2023·National Institute of Animal Science, South Korea·View original on PubMed

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Original publication title: Multi-organ metastases of primary chondrosarcoma of the mammary gland of a spayed Toy Poodle.

Species:
dog
Canine mammary tumorsStomach & digestionDogs

Plain-English summary

A 12-year-old spayed female Toy Poodle was found to have a serious condition called chondrosarcoma, a type of cancer that started in her mammary gland and spread to multiple organs, including her lungs, liver, and kidneys. Unfortunately, the cancer had progressed significantly by the time of examination, showing various nodules in these organs. This case is notable as it is the first reported instance of this type of cancer spreading from the mammary gland in a dog. Sadly, the outcome was not positive, and the dog did not survive.

People also search for: Toy Poodle cancer symptoms · dog mammary gland tumor treatment · multi-organ cancer in dogs

Abstract

We report the clinical and histopathological findings associated with multi-organ metastases of primary mammary chondrosarcoma in a 12-year-old spayed female Toy Poodle. At post-mortem examination, multifocal, sharply demarcated, grey-white to bright brown, round nodules of variable size were randomly distributed in the lungs, myocardium, liver, pancreas, spleen, intestinal tract and kidneys. Histologically, immature cartilage structures and primitive mesenchymal cells were seen in these organs. Neoplastic cells located in the cartilaginous basophilic extracellular matrix had cytoplasmic vacuolation and round vesicular nuclei and were stained with Safranin O and Alcian blue. To the best of our knowledge, this is the first report of a multi-organ metastatic chondrosarcoma that originated in the mammary gland of a dog.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37352824/