Peer-reviewed veterinary case report
Myeloperoxidase and antioxidant levels in lean and obese dogs
By Paulo, Rodrigo Rodrigues et al.·Published in Veterinary research communications·2023·Department of Veterinary Clinic, Brazil·View original on PubMed →
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Original publication title: Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs.
- Species:
- dog
Plain-English summary
A study looked at 32 dogs to compare those at a healthy weight with obese dogs to see how obesity affects certain blood markers. The obese dogs had higher body weight, blood pressure, and levels of a specific enzyme (myeloperoxidase) linked to inflammation. This suggests that being overweight can lead to increased inflammation and health risks. The researchers found that the longer a dog was obese, the more pronounced these changes were. While the findings indicate obesity can affect blood health, more research is needed to understand the antioxidant levels in these dogs.
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Abstract
The study aimed to assess plasma Myeloperoxidase enzyme (MPO) and Ferric-reducing antioxidant power (FRAP) in obese dogs and compare them with ideal body weight dogs. Thirty-two dogs were distributed into two groups according to a 9-point body condition score (BCS), as follows: Control group (n = 16), dogs with a BCS of 4 or 5; Obese group (n = 16), dogs with a BCS of 8 or 9. Plasma MPO and FRAP assays, neutrophil count, lipid profile (cholesterol and triglycerides), and systolic blood pressure (SBP) were evaluated in both groups. The duration of obesity was defined based on history. The obese group showed higher values for body weight, BCS, SBP, neutrophil count, triglycerides, and MPO than the Control group. A positive correlation was observed between MPO concentrations and BCS and body weight. FRAP concentrations showed a positive correlation with the duration of obesity. The results suggested that an inflammatory state caused by obesity may promote increased neutrophil count and MPO concentrations, besides the positive correlation between MPO with BCS and body weight. The obesity in dogs promoted slight active MPO elevation, influenced by body weight, BCS, and neutrophil count. The FRAP assay did not show the expected reduction and, therefore, needs further investigation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36572754/