Peer-reviewed veterinary case report
Neuroendocrine breast tumor with lymph node spread in a dog
By Nakahira, R et al.·Published in Journal of comparative pathology·2015·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Neuroendocrine carcinoma of the mammary gland in a dog.
- Species:
- dog
Plain-English summary
A 10-year-old female border collie was brought to the vet with a 2 cm mass in her fifth mammary gland. The mass was grey-white and was found to be a neuroendocrine carcinoma, a type of cancer that can spread to other parts of the body. Unfortunately, the cancer had already spread to her inguinal lymph node. Treatment options would typically include surgery and possibly chemotherapy, but the specific outcome for this dog isn't provided. It's important for pet owners to monitor any unusual lumps or masses and consult their veterinarian promptly.
People also search for: dog mammary tumor treatment · border collie cancer symptoms · dog lump near nipple
Abstract
A 10-year-old female border collie was presented with a mass (2 cm diameter) in the fifth mammary gland. The mass was located in the subcutis and the cut surface was grey-white in colour. Microscopically, the mass was composed of tumour cells arranged in nests of various sizes separated by delicate fibrovascular stroma. The tumour cells had small, round hypochromatic nuclei and abundant cytoplasm. Metastases were observed in the inguinal lymph node. Immunohistochemically, most tumour cells expressed cytokeratin (CK) 20, chromogranin A, neuron-specific enolase, synaptophysin and oestrogen receptor-β, but not low molecular weight CK (CAM5.2), p63 and insulin. Ultrastructurally, the tumour cells contained a large number of electron-dense granules corresponding to neuroendocrine granules. Based on these findings, this case was diagnosed as a neuroendocrine carcinoma of the mammary gland.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25670668/