Peer-reviewed veterinary case report
Oclacitinib Intoxication.
- Journal:
- Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
- Year:
- 2025
- Authors:
- Lister, Sara et al.
- Affiliation:
- ASPCA Animal Poison Control Center · United States
Plain-English summary
Recently, there have been cases of pets getting sick after eating too much oclacitinib, a chewable medication that is often flavored to make it more appealing. Symptoms of this overdose can include vomiting, diarrhea, stomach pain, being very tired or less alert than usual, and even serious issues like heart problems and kidney damage. Both dogs and cats have shown these signs, and in some cases, it has led to severe health problems or death. If a pet is suspected of having taken too much oclacitinib, it's important for veterinarians to monitor them closely and consider contacting a poison control center for guidance. The situation can be serious, so prompt action is crucial.
Abstract
BACKGROUND: Since the release of chewable flavored oclacitinib, household pets are ingesting larger quantities and are experiencing signs of toxicosis that have not been noted previously. KEY FINDINGS: Reports of intoxication have included gastrointestinal signs (vomiting, diarrhea, abdominal pain), cardiovascular signs (rhythm disturbances, hypotension, new onset heart murmur), CNS signs (lethargy, dull mentation, elevated nictitans), acute kidney injury in both dogs and cats, hepatotoxicity, and death. SIGNIFICANCE: When overdoses occur with meaningful clinical signs, clinicians are urged to provide proactive monitoring and treatment. Consultation with a poison control center and adverse event reporting to the manufacturer and the Food and Drug Administration are recommended.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40254916/