Peer-reviewed veterinary case report
Octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor.
- Journal:
- Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
- Year:
- 2012
- Authors:
- Nahab, Fatta B et al.
- Affiliation:
- Department of Neurology · United States
Abstract
Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22454323/