Peer-reviewed veterinary case report
Dog with ovarian embryonal carcinoma causing abdominal mass and fluid
By Banco, B et al.·Published in Journal of comparative pathology·2017·Dipartimento di Medicina Veterinaria, Italy·View original on PubMed →
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Original publication title: Ovarian Embryonal Carcinoma in a Dog.
- Species:
- dog
Plain-English summary
A 17-month-old female Doberman Pinscher was taken to the vet because of an abdominal mass and fluid buildup in her belly. Surgery revealed a large tumor replacing her right ovary, along with several other nodules in her abdomen. The vet removed the affected ovary and uterus, and tests showed the tumor was a type of cancer called ovarian embryonal carcinoma, which is rare in dogs. This case highlights the importance of considering aggressive ovarian tumors in young dogs when they show similar symptoms.
People also search for: dog abdominal mass · Doberman Pinscher ovarian cancer · dog ascites treatment
Abstract
A 17-month-old female doberman pinscher was referred for an abdominal mass and ascites. Exploratory laparotomy revealed the presence of a large neoplastic mass replacing the right ovary and associated with multiple mesovarian, mesometrial and peritoneal nodules. An ovariohysterectomy was performed. Grossly, the tumour was soft and multilocular with large areas of haemorrhage and necrosis. Microscopically, it was infiltrative and composed of round and polygonal cells arranged respectively in solid sheets or forming distorted tubular structures separated by thick fibrovascular septae. Tubules contained necrotic debris, proteinaceous fluid or small endoluminal papillary structures. Marked cellular atypia, multiple neoplastic emboli and high mitotic count were observed. Immunohistochemically, the round cells uniformly expressed placental alkaline phosphatase, while the polygonal cells arranged in tubules and papillae expressed cytokeratin (CK) AE1/AE3 and CK7. A final diagnosis of metastasizing ovarian embryonal carcinoma (EC), a primitive germ cell tumour characterized by rudimentary epithelial differentiation was made. Canine ovarian EC should be considered as a differential diagnosis for undifferentiated aggressive ovarian tumours in young dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29169625/