Peer-reviewed veterinary case report
High alpha-enolase levels linked to worse survival in dog mammary
By Chu, Pei-Yi et al.·Published in BMC veterinary research·2011·Department of Pathology·View original on PubMed →
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Original publication title: Overexpression of α-enolase correlates with poor survival in canine mammary carcinoma.
- Species:
- dog
Plain-English summary
A study found that in dogs with mammary tumors, overexpression of a protein called alpha-enolase (ENO1) was linked to a poorer chance of survival. Out of 50 dogs with malignant mammary tumors, 9 showed high levels of this protein, which was associated with shorter survival times. This suggests that testing for ENO1 could help veterinarians predict how well a dog might do after being diagnosed with mammary cancer.
People also search for: dog mammary tumor prognosis · canine breast cancer survival rate · alpha-enolase in dogs
Abstract
BACKGROUND: α-Enolase (ENO1) is a key glycolytic enzyme implicated in the development of many human cancers including breast cancer. Increased expression of ENO1 has recently been reported in estrogen (ER)-positive human breast cancer patients. The present study examined the expression of ENO1 and assessed its significance in canine mammary carcinoma. RESULTS: Immunohistochemical staining was employed to investigate the expression of ENO1 in 82 cases of canine mammary tumor (32 benign tumors and 50 carcinomas). Quantification of immunohistochemistry was carried out using Quick score and the results showed cytoplasmic ENO1 overexpression in 9 of the 50 carcinomas (18%). Overexpression of ENO1 correlated significantly with shorter cause-specific survival (P = 0.019), but was not associated with ER positivity in canine mammary carcinoma. CONCLUSIONS: Our findings suggest that overexpression of ENO1 may be used as a prognostic marker for poor outcome in canine mammary carcinoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22014164/