Peer-reviewed veterinary case report
How hormone and gene tests help classify dog mammary tumors
By Komatsu, Takahiro et al.·Published in The Journal of veterinary medical science·2012·Department of Small Animal Clinical Sciences, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Pathological classification of canine mammary tumor based on quantifying mRNA levels of hormonal receptors, SATB1, and Snail in tissue and fine needle biopsy samples.
- Species:
- dog
Plain-English summary
A dog with a mammary tumor underwent a fine needle biopsy (FNB) to help determine if the tumor was cancerous. The tests looked at gene expressions related to hormonal receptors and other markers. The results showed that in malignant tumors, there were low levels of hormonal receptors and high levels of certain markers, which helped classify the tumors correctly in a significant number of cases. This method could potentially allow for easier diagnosis of tumor malignancy without needing anesthesia, helping vets make better treatment decisions before surgery.
People also search for: dog mammary tumor diagnosis · fine needle biopsy for dog tumors · canine mammary cancer treatment
Abstract
Cytological diagnosis is not generally conclusive enough to identify histopathological malignancy in canine mammary tumors (CMTs). To establish cytological examination using fine needle biopsy (FNB) samples, gene expressions of hormonal receptors, human epidermal growth factor receptor 2 (HER2), and transcription regulators (Special AT-rich binding protein 1: SATB1 and Snail) were investigated in both tissue and FNB samples of CMTs. In tissue samples of malignant CMTs, especially invasive ones, low expressions of hormonal receptors and high expressions of SATB1 and Snail were detected. On discriminant analysis of tissue samples, 73.2% of CMTs were correctly classified according to histopathological examinations. In FNB samples of malignant CMTs, low expressions of hormonal receptors were detected. On discriminant analysis of FNB samples, 74.2% of CMTs were correctly classified according to histopathological examination. In conclusion, FNB gene expressions had a utility for diagnosis of CMTs malignancy in some degree. By researching more sensitive genes for malignant CMTs, the gene examination of FNB samples from CMTs will become a useful diagnostic tool that can be performed easily without anesthesia and could predict tumor malignancy and invasion prior to surgical removal.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22230980/