Peer-reviewed veterinary case report
Toceranib phosphate targets growth receptors in canine mammary tumors
By Gattino, Francesca et al.·Published in The Veterinary record·2018·Department of Veterinary Sciences, Italy·View original on PubMed →
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Original publication title: PDGFR-α, PDGFR-β, VEGFR-2 and CD117 expression in canine mammary tumours and evaluation of the in vitro effects of toceranib phosphate in neoplastic mammary cell lines.
- Species:
- dog
Plain-English summary
A study looked at canine mammary tumors (CMTs), which are common in female dogs, to see how certain proteins related to tumor growth might be targeted for treatment. Researchers found that specific receptors were present in many of the tumors, suggesting they could be potential targets for therapy. They tested a drug called toceranib phosphate in a lab setting and found it slightly reduced the growth of one type of mammary tumor cell. However, more research is needed to understand how effective this treatment could be in actual dogs with these tumors.
People also search for: dog mammary tumor treatment · toceranib phosphate for dogs · canine breast cancer symptoms
Abstract
Canine mammary tumours (CMTs) are one of the most common malignancies in bitches. Platelet-derived growth factor receptor (PDGFR) α and β, vascular endothelial growth factor receptor-2 (VEGFR-2) and CD117 are tyrosine kinase receptors involved in several tumours and represent suitable targets for specific therapy with toceranib phosphate. The purpose of this study was to evaluate the expression of these receptors in the pathogenesis and progression of CMTs. PDGFRα, PDGFRβ, VEGFR-2 and CD117 were expressed in 46/83 (55.4 per cent), 33/83 (39.8 per cent), 46/83 (55.4 per cent) and 32/83 (38.5 per cent) of CMTs, respectively. Immunohistochemical results showed a statistically significant loss of PDGFRα and PDGFRβ expression in simple carcinomas compared with complex/mixed carcinomas. Protein expression by western blot revealed specific bands corresponding to PDGFRα and VEGFR-2 in 3/7 and in 1/7 cell lines. Moreover, in vitro treatment showed that toceranib phosphate weakly reduced cell proliferation in one canine mammary cell line. Before considering TKR inhibitors for possible therapeutic approaches, actually further studies are necessary to evaluate the effect of these drugs on CMTs in vivo.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29440590/