Peer-reviewed veterinary case report
p62 DNA vaccine tested in dogs with mammary tumors
By V. Gabai et al.·Published in OncoTarget·2014·View original on Semantic Scholar →
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Original publication title: Pilot study of p62 DNA vaccine in dogs with mammary tumors
- Species:
- dog
Plain-English summary
A group of dogs with mammary tumors received a p62 DNA vaccine to see if it could help shrink or stabilize their tumors. The treatment showed promising results, as it reduced or stopped the growth of the tumors without causing significant side effects. The dogs also showed signs of immune response, which is a good indication that the vaccine was working. This study suggests that the p62 DNA vaccine could be a potential new option for treating cancer in dogs and may lead to further research for human use.
People also search for: dog mammary tumor treatment · p62 DNA vaccine for dogs · canine cancer vaccine options
Abstract
Our previous data demonstrated profound anti-tumor and anti-metastatic effects of p62 (sqstm1) DNA vaccine in rodents with various types of transplantable tumors. Testing anti-cancer medicine in dogs as an intermediary step of translational research program provides two major benefits. First, clinical data collected in target animals is required for FDA/USDA approval as a veterinary anti-cancer drug or vaccine. It is noteworthy that the veterinary community is in need of novel medicine for the prevention and treatment of canine and feline cancers. The second more important benefit of testing anti-cancer vaccines in dogs is that spontaneous tumors in dogs may provide invaluable information for human trials. Here, we evaluated the effect(s) of p62 DNA vaccine on mammary tumors of dogs. We found that p62 DNA vaccine administered i.m. decreased or stabilized growth of locally advanced lesions in absence of its overall toxic effects. The observed antitumor activity was associated with lymphocyte infiltration and tumor encapsulation via fibrotic reaction. This data justifies both human clinical trials and veterinary application of p62 DNA vaccine.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/25296974