Peer-reviewed veterinary case report
Pain relief and heart effects of ketamine-fentanyl in dogs
By de Moura, Rauane Sousa et al.·Published in BMC veterinary research·2022·Department of Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy.
- Species:
- dog
Plain-English summary
Seventeen female dogs undergoing mastectomy were given either ketamine, fentanyl, or a combination of both to manage pain during and after surgery. The treatments effectively reduced pain without causing significant breathing or heart rate issues. The combination of ketamine and fentanyl showed promising results, maintaining adequate drug levels in the dogs' systems for effective pain relief. Overall, the dogs tolerated the treatments well and experienced good pain management throughout the procedure and recovery.
People also search for: dog mastectomy pain management · ketamine fentanyl for dogs · post-surgery care for dogs
Abstract
BACKGROUND: The analgesic and cardiorespiratory effects of ketamine, fentanyl, or ketamine-fentanyl constant rate infusion (CRI) in dogs undergoing mastectomy were evaluated. Seventeen female dogs received CRI of ketamine (GK [n = 6]: bolus 0.5 mg/kg; CRI 20 µg/kg/min in intra- and postoperative periods], fentanyl (GF [n = 5]: bolus 20 µg/kg; intraoperative CRI 5 20 µg/kg/hour and postoperative CRI 2 20 µg/kg/hour), or combination of ketamine-fentanyl (GKF [n = 6]: aforementioned doses) for 8 h. Cardiorespiratory, blood gas analyses, plasma drug concentrations, sedation score (SS), Pain Scores were evaluated. RESULTS: The heart rate decreased in the GF and GKF (p < 0.04); the mean arterial pressure was lower in the GKF than in the GK at 35 min (p < 0.001). Maximum plasma concentrations were observed 5 min after bolus in the GK (2847.06 ± 2903.03 ng/mL) and GKF (2811.20 ± 1931.76 ng/mL). Plasma concentration in intraoperative period of ketamine was of > 100 ng/mL in 5/5 and 2/5 animals in the GKF and GK, respectively; and > 1.1 ng/mL of fentanyl in 4/5 and 3/5 in GKF and GF, respectively. CONCLUSION: Ketamine with/without fentanyl provided analgesia without significant cardiorespiratory and guaranteed the minimal plasma levels with analgesic potential during the 8 h.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35701767/