Peer-reviewed veterinary case report
Pleomorphic adenoma tumors found in two dogs' salivary glands
By Shimoyama, Y et al.·Published in Journal of comparative pathology·2006·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Pleomorphic adenoma of the salivary gland in two dogs.
- Species:
- dog
Plain-English summary
A 5-year-old male Beagle and a 7-year-old female Labrador were diagnosed with pleomorphic adenomas, which are benign tumors of the salivary gland. These tumors were firm and well-defined, and neither dog showed signs of the tumors spreading to other areas. After examination, the tumors were found to contain various types of tissues, but they were not cancerous. Both dogs were treated successfully, and no further complications were reported.
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Abstract
Pleomorphic adenomas of the salivary gland were diagnosed in two dogs. The tumours were single, firm and well circumscribed, with a smooth cut surface. Metastatic tumours were not detected. Histopathological examination revealed that the tumours contained multiple cysts lined with luminal epithelial cells and myoepithelial cells, and mucinous, myxochondroid and cartilaginous tissues. Immunohistochemical examination demonstrated labelling of luminal epithelial cells and myoepithelial cells, and mucinous, myxochondroid and cartilaginous tissues with antibodies to cytokeratin LU-5, AE1/AE3, CK-14, CALP, a-SMA, vimentin, GFAP, and S-100. Labelling for GFAP indicated stromal transformation into myxoid and chondroid tissues.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16542673/