Peer-reviewed veterinary case report
Blood clotting and antithrombin III levels in diabetic dogs
By Milczak, Andrzej et al.·Published in BMC veterinary research·2022·Department and Clinic of Animal Internal Diseases·View original on PubMed →
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Original publication title: Procoagulant and anticoagulant plasma indicators in diabetic dogs showing increased antithrombin III levels in canine diabetes mellitus.
- Species:
- dog
Plain-English summary
A group of 20 diabetic dogs showed higher levels of a protein called antithrombin III (ATIII), which helps prevent blood clots, compared to 15 healthy dogs. In fact, 90% of the diabetic dogs had significantly elevated ATIII levels, suggesting it may play a protective role against blood clots in these pets. While this finding is interesting, the exact impact of ATIII in diabetic dogs is still not fully understood. If your dog has diabetes, it’s worth discussing these findings with your veterinarian to understand any potential risks or treatments.
People also search for: dog diabetes symptoms · elevated antithrombin III in dogs · diabetic dog blood clot risk
Abstract
BACKGROUND: Diabetes mellitus (DM) often leads to dangerous thromboembolic complications in humans. DM is also a relatively common endocrinopathy of dogs. There is scarce information regarding procoagulant and anticoagulant plasma indicators in this disease. The aim of the study was to evaluate the levels of the selected plasma haemostatic parameters in dogs suffering from diabetes. The study group consisted of 20 dogs meeting all the inclusion criteria, with fasting glycaemia exceeding 11.1 mmol/l. The control group consisted of 15 healthy dogs presented for routine examination. An evaluation of the prothrombin time (PT); and fibrinogen, D-dimer and antithrombin III (ATIII) levels was performed. RESULTS: Except for ATIII activity, the haemostatic parameter differences were not statistically significant. High values of ATIII activity were observed in 90% of diabetic dogs. On average, the values amounted to 166.6% and were 31.4% higher than those in the control group. The ATIII activity in the diabetic group was significantly higher than that in the control group (p = 0.0004). CONCLUSIONS: Here, we report elevated levels of ATIII in diabetic dogs. This finding may suggest the protective role of ATIII against potential thrombotic events. However, the exact role of ATIII in dog diabetes remains unclear.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35305618/