Peer-reviewed veterinary case report
Older female dog with vaginal tumor linked to high progesterone levels
By Ferré-Dolcet, L et al.·Published in BMC veterinary research·2020·Department of Animal Medicine, Italy·View original on PubMed →
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Original publication title: Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch.
- Species:
- dog
Plain-English summary
An 11-year-old female Labrador retriever was brought to the vet because she was unable to urinate, had constipation, and a vaginal mass was protruding. Tests showed she had high progesterone levels, and despite trying medications to reduce the mass, her condition didn't improve. Eventually, the vet performed surgery to remove her ovaries and uterus, which revealed a tumor on one ovary. After the surgery, her progesterone levels dropped to normal, and the vaginal mass significantly shrank. She has since recovered well and can urinate normally.
People also search for: dog vaginal mass treatment · Labrador retriever urinary problems · high progesterone in dogs
Abstract
BACKGROUND: This is the first report about a vaginal leiomyoma concomitant with an ovarian luteoma in a bitch. CASE PRESENTATION: A 11-year-old intact female Labrador retriever was referred because of anuria, constipation and protrusion of a vaginal mass through the vulvar commissure. The bitch had high serum progesterone concentration (4.94 ng/ml). Because of the possibility of progesterone responsiveness causing further increase of the vaginal mass and since the bitch was a poor surgical candidate a 10 mg/kg aglepristone treatment was started SC on referral day 1. A computerized tomography showed a 12.7 × 6.5 × 8.3 cm mass causing urethral and rectal compression, ureteral dilation and hydronephrosis. A vaginal leiomyoma was diagnosed on histology. As serum progesterone concentration kept increasing despite aglepristone treatment, a 0.02 ng/mL twice daily IM alfaprostol treatment was started on day 18. As neither treatment showed remission of clinical signs or luteolysis, ovariohysterectomy was performed on referral day 35. Multiple corpora lutea were found on both ovaries. On histology a luteoma was diagnosed on the left ovary. P4 levels were undetectable 7 days after surgery. Recovery was uneventful and 12 weeks after surgery tomography showed a reduction of 86.7% of the vaginal mass. The bitch has been in good health and able to urinate without any complication ever since. CONCLUSIONS: This case demonstrates the importance of identifying progesterone related conditions as well as the importance of judiciously using a combined medical and surgical approach.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32778114/