Peer-reviewed veterinary case report
Survival times for different types of dog mammary tumors
By Rasotto, Roberta et al.·Published in Veterinary pathology·2017·1 Dick White Referrals, United Kingdom·View original on PubMed →
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Original publication title: Prognostic Significance of Canine Mammary Tumor Histologic Subtypes: An Observational Cohort Study of 229 Cases.
- Species:
- dog
Plain-English summary
A group of 229 female dogs with mammary tumors underwent a study to determine how different tumor types affect survival rates. Dogs with benign tumors generally had a good prognosis, while those with certain aggressive types, like anaplastic carcinoma and carcinosarcoma, had very poor outcomes, with survival times as short as three months. The study found that tumor size and specific histologic features were important in predicting how likely the cancer was to spread or come back after treatment. This information can help veterinarians provide better care and advice for dogs diagnosed with mammary tumors.
People also search for: dog mammary tumor prognosis · canine cancer survival rates · treatment for dog mammary carcinoma
Abstract
Histopathology is considered the gold standard diagnostic method for canine mammary tumors. In 2011, a new histologic classification for canine mammary tumors was proposed. The present study was a 2-year prospective study that validated the 2011 classification as an independent prognostic indicator with multivariate analysis in a population of 229 female dogs, identifying subtype-specific median survival times (MST) and local recurrence/distant metastasis rates. Dogs with benign tumors and carcinoma arising in benign mixed tumors all had an excellent prognosis. Dogs with complex carcinoma and simple tubular carcinoma also experienced prolonged survival. Those with simple tubulopapillary carcinoma, intraductal papillary carcinoma, and carcinoma and malignant myoepithelioma had a more than 10-fold higher risk of tumor-related death. The prognosis was even worse for adenosquamous carcinoma (MST = 18 months), comedocarcinoma (MST = 14 months), and solid carcinoma (MST = 8 months). The most unfavorable outcome was for anaplastic carcinoma (MST = 3 months) and carcinosarcoma (MST = 3 months), which also had the highest metastatic rates (89% and 100%, respectively). Adenosquamous carcinoma exhibited the highest local recurrence rate (50%). In the same canine population, the tumor diameter was recognized as a strong predictor of local recurrence/distant metastasis and an independent prognosticator of survival in the multivariate analysis. Excision margins were predictive only of local recurrence, whereas lymphatic invasion and histologic grade were predictive of local recurrence/distant metastasis and survival, although only in univariate analyses. In conclusion, this study validated the 2011 classification scheme and provided information to be used in the clinical setting and as the basis for future prognostic studies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28355108/