Peer-reviewed veterinary case report
Midline brain shift shortens survival in dogs with nasal cancer
By Wada, Yusuke et al.·Published in The Journal of veterinary medical science·2018·Osaka Prefecture University, Japan·View original on PubMed →
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Original publication title: Prognostic significance of midline shift of the olfactory or frontal lobes of the brain in canine nasal carcinomas treated by palliative radiotherapy: a pilot study.
- Species:
- dog
Plain-English summary
A dog with nasal cancer that had spread to the brain was treated with palliative radiotherapy. Researchers found that dogs whose tumors caused a shift in the brain's midline had a much shorter survival time—about 64 days—compared to those without this shift, who lived an average of 208 days. This suggests that the presence of a midline shift is an important factor in predicting how long a dog might survive after treatment for nasal cancer.
People also search for: dog nasal cancer treatment · canine brain tumor prognosis · palliative care for dogs with cancer
Abstract
Canine nasal carcinomas are often treated with radiotherapy. Presence of lysis of the cribriform plate by tumor invasion (stage 4 by modified Adams's staging system) is a well-known prognostic factor. In this study, dogs with stage 4 disease were divided into two subgroups based on the presence or absence of midline shift of the olfactory or frontal lobes of the brain (Stage 4a: without presence of midline shift. Stage 4b: with midline shift). The median survival time of dogs with midline shift was significantly shorter than that of dogs without midline shift (64 vs. 208 days). Our results indicate that the finding of a midline shift might have a prognostic significance in dogs with nasal carcinoma treated with radiotherapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30305466/