Peer-reviewed veterinary case report
HER2 and MUC1 levels linked to dog mammary cancer spread risk
By Campos, Liliane C et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2015·Department of General Pathology, Brazil·View original on PubMed →
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Original publication title: Prognostic significance of tissue and serum HER2 and MUC1 in canine mammary cancer.
- Species:
- dog
Plain-English summary
A group of 48 female dogs with mammary cancer was studied to see how certain proteins in their blood and tumor tissues could indicate whether the cancer had spread to nearby lymph nodes. The researchers found that dogs with metastasis had higher levels of a protein called MUC1 in their blood compared to those without metastasis or healthy dogs. However, levels of another protein, HER2, did not show a similar pattern. This suggests that checking MUC1 levels could help veterinarians determine if a dog’s mammary cancer has spread, while HER2 levels may not be as useful for this purpose.
People also search for: dog mammary cancer treatment · MUC1 levels in dogs · canine cancer metastasis signs
Abstract
The aim of our study was to compare serum levels and protein tissue of human epidermal growth factor receptor-2 proto-oncogene (HER2) and mucin 1 (MUC1) using an antigen-capture enzyme-linked immunosorbent assay and immunohistochemistry (IHC) in canine mammary carcinomas and investigate how the 2 markers correlate with dogs with metastasis and without metastasis to a regional lymph node. Forty-eight female dogs were selected, including 14 with non-metastatic cancer, 14 with lymph node metastasis, and 20 healthy animals. Serum samples were collected from all the animals and tissues from 28 dogs with malignant mammary tumor with or without metastasis for evaluated HER2 and MUC1 expression. Tissue sample were evaluated for MUC1 and HER2 immunoexpression by IHC. The results showed measurable serum levels of MUC1 and HER2 in all groups. While serum MUC1 levels were significantly higher in animals with metastasis than the other 2 groups, no increase was observed in HER2 serum levels. The MUC1 IHC results showed that only membrane immunostaining was significantly different between the groups. Statistically, there was an association between immunostaining and the serum HER2 levels. Our results indicate that serum concentrations of HER2 and the IHC staining pattern for HER2 in primary tumor do not correlate with the presence of regional metastasis. However, increased concentrations of MUC1 in the serum of dogs with mammary cancer are associated with the presence of metastasis to regional lymph nodes. A membrane pattern of IHC staining for MUC1 in the primary tumor suggests that metastases to regional lymph node are present.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26179096/