Peer-reviewed veterinary case report
How lymph node cancer spread affects survival in dogs with mammary
By Szczubiał, M & Łopuszynski, W·Published in Veterinary and comparative oncology·2011·Department and Clinic of Animal Reproduction·View original on PubMed →
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Original publication title: Prognostic value of regional lymph node status in canine mammary carcinomas.
- Species:
- dog
Plain-English summary
A group of 51 female dogs with mammary tumors underwent surgery to remove the affected glands and nearby lymph nodes. After the surgery, the lymph nodes were tested for cancer spread. The results showed that dogs without cancer in their lymph nodes had a better chance of living longer and being cancer-free compared to those with larger metastases (cancer spread) in their lymph nodes. However, there was no significant difference in outcomes between dogs with no metastases and those with smaller micrometastases. This information can help veterinarians assess the prognosis for dogs with mammary cancer.
People also search for: dog mammary cancer prognosis · female dog tumor surgery · lymph node metastasis in dogs
Abstract
In this study, we have determined the prognostic value of the presence of the micrometastases and metastases greater than 2 mm in the regional lymph nodes for bitches with mammary carcinomas. The study involved 51 dogs diagnosed with a single malignant epithelial tumour in the 4th or 5th mammary gland. All animals underwent regional mastectomy; the 4th and 5th mammary glands were removed together with the inguinal lymph node. The lymph nodes were examined immunohistochemically using the anti-cytokeratin antibody, clone AE1/AE3. The bitches were followed up every 6 months for 2 years after surgery to determine the disease-free survival (DFS) and overall survival (OS). The Kaplan-Meier analysis showed a statistically significant difference in DFS and OS only between the group of bitches without metastases and the group with lymph node metastases greater than 2 mm. No significant differences between these two groups versus bitches with lymph node micrometastases were found.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22077411/