Peer-reviewed veterinary case report
Metronomic chlorambucil chemo helped some dogs with cancer live longer
By Leach, T N et al.·Published in Veterinary and comparative oncology·2012·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer.
- Species:
- dog
Plain-English summary
A group of 36 dogs with different types of cancer received a daily low-dose chemotherapy called metronomic chlorambucil to see how well it worked and if it caused any serious side effects. The treatment was generally well tolerated, with no severe side effects reported. Four dogs showed signs of improvement, with three achieving complete remission for over 35 weeks, while one had partial remission lasting 39 weeks. Overall, many dogs experienced stable disease, and the average survival time was about 153 days.
People also search for: dog cancer treatment options · chlorambucil for dogs · dog chemotherapy side effects · mast cell tumor in dogs · soft tissue sarcoma treatment for dogs
Abstract
The purpose of this study was to assess the toxicoses and antitumor activity of metronomic chlorambucil at a dosage of 4 mg m(-2) daily in dogs with naturally occurring cancer. Thirty-six dogs were enrolled in the study. The protocol was well tolerated with no grade 3 or 4 toxicoses noted. Complete remission was achieved, and lasted over 35 weeks in three dogs (mast cell tumour, soft tissue sarcoma and thyroid carcinoma). Partial remission was noted in 1 dog with histiocytic sarcoma (39 weeks duration) for an overall remission rate of 11% (4 of 36). Stable disease was noted in 17 dogs (47%) with various other cancers. The median progression-free interval was 61 days, and the median survival time was 153 days. Chlorambucil given in a metronomic protocol showed antitumor activity in dogs with a variety of naturally occurring cancers.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22236329/