Peer-reviewed veterinary case report
How tumor grade relates to tissue changes in dog mammary cancer
By Tanaka, Y et al.·Published in Journal of comparative pathology·2020·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Relationship between Histological Grade and Histopathological Appearance in Canine Mammary Carcinomas.
- Species:
- dog
Plain-English summary
A female dog with a mammary tumor was examined to determine if it was benign or malignant. The study focused on a grading system that helps predict how aggressive the tumor might be, based on factors like cell structure and growth patterns. Researchers found that this grading system was effective, especially for tumors classified as grade II, and that looking at additional features of the tumor could provide more insight into its behavior. This information can help veterinarians make better treatment decisions for dogs with mammary tumors.
People also search for: dog mammary tumor treatment · female dog breast cancer symptoms · canine mammary carcinoma grading
Abstract
Canine mammary carcinomas are common tumours in female dogs and histopathological examination has an important role in identifying whether they are benign or malignant. The latest and most commonly used histological grading system was established by Peña et al. (2013) and is based on the extent of tubule formation, nuclear pleomorphism and number of mitoses. Before the establishment of this grading system, tumour size and classical histological indicators of malignancy such as lymphovascular invasion, infiltration into surrounding tissue, necrosis and presence of a micropapillary pattern were important predictors of biological behaviour. However, the system of Peña et al. does not consider tumour size or these histological features. Clarifying the association of these features and histological grade, especially in grade II and III carcinomas, is important. In this study, we confirmed that the system of Peña et al. is effective for predicting biological behaviour and that evaluation of histological features of malignancy reinforced histological grade, as determined by the system of Peña et al., especially in grade II carcinomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32958149/