Peer-reviewed veterinary case report
Loss of MHC class I linked to poor prognosis in dog mammary tumors
By Tanaka, Toshiyuki et al.·Published in The Journal of veterinary medical science·2013·Department of Graduate School of Life and Environmental Sciences, Japan·View original on PubMed →
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Original publication title: Relationship between major histocompatibility complex class I expression and prognosis in canine mammary gland tumors.
- Species:
- dog
Plain-English summary
A group of dogs with mammary gland tumors had their tumor tissues examined to see how a specific protein (MHC class I) related to their prognosis. The study found that dogs with mammary gland carcinomas (a type of cancer) that lost this protein had a poorer outlook, while those with complex carcinomas (a different type) generally had a good prognosis, even if they lost the protein. This suggests that the presence of MHC class I might be an important factor in determining how well dogs with mammary gland carcinomas will do after treatment.
People also search for: dog mammary gland tumor prognosis · canine cancer treatment options · MHC class I expression in dogs
Abstract
The aim of this study was to evaluate MHC class I expression and prognosis using tumor tissues surgically removed from 9 dogs with mammary gland carcinomas and from 13 dogs with complex carcinomas. We assessed MHC class I expression and its correlation with tumor size, B2M expression, infiltration of lymphocytes, histological grade and prognosis. Hematoxylin and eosin-stained sections were histologically graded using the Elston and Ellis grading method. MHC class I expression on tumor cells was evaluated using the avidin-biotin peroxidase complex method. Loss of MHC class I expression from canine mammary gland carcinomas was significantly correlated with poor prognosis (P<0.05). Loss of MHC class I expression showed no association with poor prognosis in canine mammary gland complex carcinomas, because the data were not balanced. Only 1 of 13 (7.6%) canine mammary gland complex carcinomas showed loss of MHC class I expression. All 13 of these dogs showed good prognosis. Thus, the low frequency of MHC class I expression loss from canine mammary gland complex carcinomas may be associated with good prognosis. Taken together, these results suggest that loss of MHC class I expression may be associated with poor prognosis in canine mammary gland carcinomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23728200/