Peer-reviewed veterinary case report
NF-kappaB levels linked to malignancy in dog mammary tumors
By Mkaouar, Lobna et al.·Published in The Journal of veterinary medical science·2012·Graduate School of Agricultural and Life Sciences, Japan·View original on PubMed →
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Original publication title: Relationship between NF-κB expression and malignancy of canine mammary gland tumor tissues.
- Species:
- dog
Plain-English summary
A group of dogs with mammary gland tumors was studied to see how a specific protein (NF-κB) in their tumor tissues related to the severity of their condition. The results showed that dogs with malignant (cancerous) tumors had higher levels of this protein, which was linked to larger tumor sizes and shorter survival times. In contrast, benign tumors had much lower levels of NF-κB. This suggests that measuring NF-κB levels could help veterinarians predict how aggressive a dog's mammary tumor might be and what the likely outcome could be.
People also search for: dog mammary tumor prognosis · NF-kB in dog cancer · canine mammary gland tumor treatment
Abstract
In this study, the nuclear expression of nuclear factor kappa B (NF-κB) in 48 tissues specimens from 25 canine spontaneous mammary gland tumor (MGT) patients was assessed by immunohistochemistry to compare their levels with clinical features, histological types, prognostic outcomes and proliferative activities, including the mitotic index (MI) and cylcinD1 expression. Twelve of eighteen (66.7%) malignant tumor tissues showed greater than 10% nuclear staining, while benign tumor and hyperplastic tissues showed less than 10% nuclear staining. Higher nuclear expression of NF-κB was positively correlated with larger tumor size, lymph node metastasis and higher MI; however, no correlation was observed with distant metastasis and cyclin D1 expression. Higher NF-κB nuclear expression correlated with shorter patient survival. These findings suggest that NF-κB is a useful prognostic factor for canine MGT patients.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22222165/