Peer-reviewed veterinary case report
Inflammation and fibrosis in different types of dog mammary tumors
By de Souza, Thiago Alves et al.·Published in Research in veterinary science·2018·Programa de Pó, Brazil·View original on PubMed →
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Original publication title: Relationship between the inflammatory tumor microenvironment and different histologic types of canine mammary tumors.
- Species:
- dog
Plain-English summary
A study looked at different types of mammary tumors in female dogs and how inflammation in the tumor environment might affect their behavior. It found that certain immune cells, like neutrophils and plasma cells, were linked to more aggressive tumors, while other cells were associated with less aggressive types. The researchers noted that larger areas of tumor fibrosis (scar-like tissue) were also related to more aggressive tumors. Understanding these relationships could help veterinarians better assess and treat mammary tumors in dogs.
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Abstract
Mammary neoplasms are the tumors with higher incidence in female dogs. Among the factors that contribute for the development of this and other neoplasms, the inflammatory tumor microenvironment plays a crucial role. Several studies reported important roles for lymphocytes, macrophages, plasma cells, neutrophils, eosinophils and mast cells in this context. In the present study, our aim was to evaluate the number of profile cells of inflammatory cells and area of tumor fibrosis and the relation of these features with canine mammary tumors of different histologic and clinical presentation (benign mixed tumor, carcinoma in mixed tumor, solid carcinoma and tubular carcinoma) Counting and staining of inflammatory cells and tumor fibrosis were performed through histochemistry, while counting and staining of CD4, TCD8and FOXP3lymphocytes were performed through immunohistochemistry. Statistical analysis of the association between densities of inflammatory cells, tumor fibrosis and histologic types revealed significant difference for plasma cells (p = .035), neutrophils (p = .0113), macrophages (p = .0047), and tumor fibrosis (p = .05). The found data suggest associations between high number of neutrophils and aggressive mammary tumors, between high densities of plasma cells, macrophages and CD8cells and between low number of profile cells of CD4cells and less aggressive tumors. Larger areas of tumor fibrosis showed relation to more aggressive canine mammary tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29966962/