Peer-reviewed veterinary case report
Kidney disease causing parathyroid problems in dogs
By Stillion, Jenefer R & Ritt, Michelle G·Published in Compendium (Yardley, PA)·2009·Cornell University Hospital for Animals, United States·View original on PubMed →
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Original publication title: Renal secondary hyperparathyroidism in dogs.
- Species:
- dog
Plain-English summary
A dog with chronic kidney disease can develop a condition called renal secondary hyperparathyroidism, which affects calcium levels in the body. This can lead to serious health issues, including bone problems and mineral deposits in soft tissues. Treatment options include changing the dog's diet to limit phosphorus, using medications to bind phosphorus in the intestines, and giving calcitriol (a form of vitamin D) to help manage calcium levels. While these treatments may help slow the progression of kidney disease and lower parathyroid hormone levels, the overall outlook for dogs with this condition is often not very hopeful.
People also search for: dog kidney disease symptoms · renal secondary hyperparathyroidism treatment · dog calcium levels management
Abstract
The parathyroid glands secrete parathyroid hormone (PTH), which is important for maintaining calcium homeostasis. Parathyroid gland hyperplasia and subsequent hyperparathyroidism can occur secondary to chronic renal failure in dogs, resulting in significant alterations in calcium metabolism. Renal secondary hyperparathyroidism is a complex, multifactorial syndrome that involves changes in circulating levels of calcium, PTH, phosphorus, and 1,25-dihydroxycholecalciferol (calcitriol). An increased PTH level can have deleterious effects, including soft tissue mineralization, fibrous osteodystrophy, bone marrow suppression, urolithiasis, and neuropathy. Dietary phosphorus restriction, intestinal phosphate binders, and calcitriol supplementation may slow the progression of renal disease and decrease PTH concentrations in animals with secondary hyperparathyroidism; however, the prognosis for these animals is guarded to poor.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19746344/