Peer-reviewed veterinary case report
Repetitive propofol administration in dogs and cats.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2004
- Authors:
- Matthews, Nora S et al.
- Affiliation:
- Texas A & M University · United States
Plain-English summary
In a study, researchers gave propofol, a medication often used for anesthesia, to 10 dogs and 10 cats over three days. The dogs received a dose of 6 mg per kilogram of body weight, while the cats received 10 mg per kilogram. While the dogs did not experience any breathing problems, three of the cats did have some trouble breathing. There were slight increases in a specific type of blood cell in six of the cats, but these changes were not serious. Overall, the study found that giving propofol in this way did not cause any significant harmful effects in either species.
Abstract
A bolus of propofol was administered to 10 dogs (6 mg/kg intravenously [IV]) and 10 cats (10 mg/kg IV) on three consecutive days. The occurrence of apnea, heart and respiratory rates, blood pressure, time to movement, and changes in a complete blood count and biochemical profile were recorded. Apnea was not seen in the dogs but was seen in three cats. Slight increases in the number of Heinz bodies were seen in six cats, but the increases were not considered clinically significant. No apparent cumulative adverse effects were seen from a bolus of bisulfite-containing propofol, administered on three consecutive days.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15238555/