Sensitivity of Dermatophytes to Terbinafine: World Experience and Recent Findings from Kazakhstan.

Abstract

<b>Background/Objectives</b>: This article describes the results of an analysis of the sensitivity of dermatophytosis pathogens to terbinafine, conducted by the authors based on a review of available scientific publications and data from their own research. Currently, no information is available on the sensitivity of Kazakh isolates obtained from patients at dermatological clinics. The aim of this study was to compile data on the resistance of dermatophytes to terbinafine over the past decade worldwide and investigate the sensitivity of dermatophyte isolates collected from patients in Astana, Kazakhstan, to terbinafine. <b>Methods</b>: A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, utilizing the Pubmed and Cochrane Library databases with specific keywords. The sensitivity of the dermatophytes to terbinafine was assessed using EUCAST E.Def 11.0 method. <b>Results</b>: Screening of terbinafine susceptibility among Kazakh clinical isolates revealed that all <i>Microsporum canis</i> strains (57/57, 100%) were sensitive to the drug. Among 33 <i>Trichophyton</i> spp. isolates, 4 (12.1%) demonstrated resistance to terbinafine, with MIC values ranging from 0.125 to 1.5 µg/mL. The resistant isolates belonged to the species <i>T. indotineae</i>, <i>T. interdigitale</i>, and <i>T. mentagrophytes</i>. <b>Conclusions</b>: Terbinafine remains highly effective against <i>Microsporum canis</i> in Kazakhstan, while a small proportion of <i>Trichophyton</i> isolates show resistance. Continuous monitoring of dermatophyte susceptibility is warranted to guide effective treatment.