Peer-reviewed veterinary case report
Blood protein changes in female dogs with large or metastatic mammary
By Tecles, Fernando et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2009·Animal Medicine and Surgery Department, Spain·View original on PubMed →
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Original publication title: Serum acute phase protein concentrations in female dogs with mammary tumors.
- Species:
- dog
Plain-English summary
A group of female dogs aged 8 to 12 years with mammary tumors were studied to see how certain proteins in their blood changed based on the severity of their condition. The researchers found that dogs with larger tumors (over 5 cm) or those that had spread to other parts of the body showed higher levels of specific proteins linked to inflammation. Additionally, dogs with mammary tumors and other health issues had elevated levels of C-reactive protein, while those with metastasis had lower levels of albumin. This suggests that the presence of mammary tumors can trigger an inflammatory response in these dogs, influenced by factors like tumor size and spread.
People also search for: dog mammary tumor symptoms · female dog cancer treatment · elevated C-reactive protein in dogs · dog tumor size and prognosis
Abstract
Acute phase proteins (APPs) are proteins whose concentrations in serum change after any inflammatory stimulus or tissue damage. The aim of the current study was to evaluate 3 positive APPs (C-reactive protein, serum amyloid A, and haptoglobin) and 1 negative APP (albumin) in female dogs with mammary neoplasia. Acute phase proteins were studied in 70 female dogs aged 8-12 years in the following groups: healthy (n = 10); mammary tumors in stages I (n = 19), II (n = 5), III (n = 6), IV (n = 5), and V (n = 7); and with mammary neoplasia plus a concomitant disease (n = 18). In animals with mammary neoplasia, significant increases of positive APPs were only detected in those that had metastasis or a neoplasm with a diameter greater than 5 cm and ulceration. Dogs with mammary neoplasia and a concomitant disease also had high C-reactive protein concentrations. Albumin concentration was decreased in animals with metastasis and with a concomitant disease. The results of the present study indicate that the acute phase response could be stimulated in female dogs with mammary gland tumors because of different factors, such as metastasis, large size of the primary mass, and ulceration or secondary inflammation of the neoplasm.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19286500/