Peer-reviewed veterinary case report
Growth hormone levels linked to canine mammary cancer outcomes
By Queiroga, Felisbina L et al.·Published in Research in veterinary science·2010·Department of Veterinary Sciences·View original on PubMed →
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Original publication title: Serum and intratumoural GH and IGF-I concentrations: prognostic factors in the outcome of canine mammary cancer.
- Species:
- dog
Plain-English summary
A study found that female dogs with mammary tumors had higher levels of growth hormone (GH) and insulin-like growth factor I (IGF-I) in their blood and tumor tissue compared to those with benign tumors or healthy dogs. These elevated hormone levels were linked to a greater chance of the cancer returning or spreading, as well as shorter survival times. While these hormone levels indicate a worse prognosis, they were not strong enough to be considered independent predictors of outcomes. This research suggests that targeting these hormones could lead to new treatments for canine mammary cancer.
People also search for: dog mammary tumor prognosis · elevated growth hormone in dogs · canine cancer treatment options
Abstract
The biological implication of the growth hormone/insulin like growth factor-I (GH/IGF-I) axis in canine mammary tumours (CMT) has been recently demonstrated, however its clinical and prognostic implications are unknown. Our aim was to investigate its prognostic significance. Hormonal determinations were done by enzyme immunoassays techniques validated for canine species in serum and tumour tissue from 32 bitches with CMT and in serum and normal mammary tissue from 10 controls. Serum and tissular GH and IGF-I concentrations were significantly higher in the case of malignant tumour compared with benign and controls. GH and IGF-I elevated concentrations were significantly associated with tumour relapse and/or metastases during follow-up and in dogs with reduced survival times; however these parameters were not independent prognostic factors in multivariate analysis. This association demonstrates a link between high serum and intratumoural GH and IGF-I concentrations and a worse prognosis and opens the possibility to new anticancer endocrine therapies in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20381105/