Peer-reviewed veterinary case report
C-reactive protein and S100A12 levels in dogs with liver disease
By Craig, S M et al.·Published in The Journal of small animal practice·2016·Gulf Coast Veterinary Specialists, United States·View original on PubMed →
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Original publication title: Serum C-reactive protein and S100A12 concentrations in dogs with hepatic disease.
- Species:
- dog
Plain-English summary
A group of dogs with liver disease had their blood tested for two markers, C-reactive protein and S100A12, to see if these levels could indicate the severity of their condition. In about 39% of the dogs, C-reactive protein levels were higher than normal, suggesting inflammation, while S100A12 was elevated in 26% of the dogs. The study found that dogs with more severe liver inflammation had higher C-reactive protein levels. This suggests that monitoring these markers could help veterinarians assess liver disease severity in dogs.
People also search for: dog liver disease symptoms · elevated C-reactive protein in dogs · liver inflammation in dogs
Abstract
OBJECTIVES: To describe serum C-reactive protein and S100A12 concentrations in dogs with hepatic disease and to determine whether there is a relationship between the concentration of either and the severity of hepatic necroinflammation. METHODS: Serum C-reactive protein and S100A12 concentrations were measured in 46 dogs undergoing hepatic biopsy. Dogs were divided into three groups: congenital portosystemic shunts, chronic hepatitis and hepatic neoplasia. The histological severity of hepatic necroinflammation was scored. RESULTS: C-reactive protein and S100A12 concentrations were greater than the upper limit of the reference intervals in 39 and 26% of dogs, respectively. There was no association of disease group with C-reactive protein (P=0·1733) or S100A12 (P=0·1513) concentrations. There was a positive correlation between serum C-reactive protein concentration and hepatic necroinflammatory activity (rs =0·428, P=0·006). CLINICAL SIGNIFICANCE: Increased serum C-reactive protein and S100A12 concentrations were observed in a subpopulation of dogs with various types of hepatic diseases, suggesting acute-phase inflammation and activation of phagocytic cells, respectively. Dogs with higher hepatic necroinflammatory activity scores tended to have higher serum C-reactive protein concentrations. Further studies are needed to confirm this finding in a larger group of dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27271454/