Peer-reviewed veterinary case report
Serum C-reactive protein and S100A12 concentrations in dogs with hepatic disease.
- Journal:
- The Journal of small animal practice
- Year:
- 2016
- Authors:
- Craig, S M et al.
- Affiliation:
- Gulf Coast Veterinary Specialists · United States
- Species:
- dog
Plain-English summary
In a study involving 46 dogs with liver disease, researchers measured two substances in their blood: C-reactive protein and S100A12. They found that about 39% of the dogs had higher levels of C-reactive protein, which is often linked to inflammation, and 26% had elevated S100A12, which is related to immune response. The study showed that dogs with more severe liver inflammation tended to have higher levels of C-reactive protein, but there was no clear link between the type of liver disease and the levels of either substance. This suggests that while some dogs with liver issues show increased inflammation, more research is needed to understand these findings better. Overall, the treatment or management of these dogs based on these markers was not directly addressed in this study.
Abstract
OBJECTIVES: To describe serum C-reactive protein and S100A12 concentrations in dogs with hepatic disease and to determine whether there is a relationship between the concentration of either and the severity of hepatic necroinflammation. METHODS: Serum C-reactive protein and S100A12 concentrations were measured in 46 dogs undergoing hepatic biopsy. Dogs were divided into three groups: congenital portosystemic shunts, chronic hepatitis and hepatic neoplasia. The histological severity of hepatic necroinflammation was scored. RESULTS: C-reactive protein and S100A12 concentrations were greater than the upper limit of the reference intervals in 39 and 26% of dogs, respectively. There was no association of disease group with C-reactive protein (P=0·1733) or S100A12 (P=0·1513) concentrations. There was a positive correlation between serum C-reactive protein concentration and hepatic necroinflammatory activity (rs =0·428, P=0·006). CLINICAL SIGNIFICANCE: Increased serum C-reactive protein and S100A12 concentrations were observed in a subpopulation of dogs with various types of hepatic diseases, suggesting acute-phase inflammation and activation of phagocytic cells, respectively. Dogs with higher hepatic necroinflammatory activity scores tended to have higher serum C-reactive protein concentrations. Further studies are needed to confirm this finding in a larger group of dogs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27271454/