Peer-reviewed veterinary case report
Magnesium levels in male dogs with perianal gland tumors
By Brodzki, Adam et al.·Published in Magnesium research·2013·Department and Clinic of Animal Surgery·View original on PubMed →
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Original publication title: Serum concentration of magnesium in dogs suffering from tumors of the perianal glands.
- Species:
- dog
Plain-English summary
A group of dogs with tumors near their rear end had their blood tested for magnesium levels to see if it could help tell the difference between benign (non-cancerous) and malignant (cancerous) tumors. The study found that dogs with malignant tumors had significantly higher magnesium levels compared to healthy dogs and those with benign tumors. Over six months, magnesium levels in dogs with benign tumors also increased, but not as much as in those with malignant tumors. This suggests that measuring magnesium levels in the blood could be a useful tool for vets when diagnosing these types of tumors in dogs.
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Abstract
The aim of this study was to determine serum magnesium concentrations in dogs with benign and malignant tumors of the perianal glands. The magnesium concentration was determined in samples taken from 45 tumor-affected and 17 healthy males. Twenty one dogs suffered from malignant tumors (Malignant group), while benign changes were diagnosed in 24 cases (Non-malignant group). All dogs with neoplastic disease were treated with antiandrogens and antiestrogens. Determination of magnesium concentrations in serum obtained from dogs before the start of treatment (baseline), and one and six months later was performed using atomic absorption spectrophotometry. One-way ANOVA and the post-hoc Tukey's HSD test were used to compare differences between the groups investigated and time-related changes. Significantly higher serum magnesium concentrations were found in the group with malignant tumors when compared to the control and non-malignant groups (P<0.001). Serum magnesium concentrations in dogs with non-malignant neoplastic changes had increased gradually by 17% and 41% at one and six months when compared to the baseline values (P<0.05). In conclusion, the malignant neoplastic process in dogs was associated with a higher baseline serum magnesium concentration. Thus, determination of the serum magnesium concentration might be helpful for diagnostic differentiation between malignant and benign perianal tumors in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23787172/