Peer-reviewed veterinary case report
D-lactate levels in dogs with parvovirus infection
By Venn, Emilee C et al.·Published in Journal of veterinary internal medicine·2020·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Serum D-lactate concentrations in dogs with parvoviral enteritis.
- Species:
- dog
Plain-English summary
A group of dogs with parvovirus infection (CPV) had higher levels of D-lactate in their blood compared to healthy dogs, indicating a potential issue with their gut health. However, these D-lactate levels did not reliably predict how severe the disease was or whether the dogs would recover. Over the first few days of treatment, the D-lactate levels decreased, but there was no clear link between these levels and the dogs' clinical condition or recovery outcomes. Ultimately, while the D-lactate levels were higher in sick dogs, they didn't provide useful information for treatment decisions.
People also search for: dog parvovirus symptoms · D-lactate levels in dogs · treatment for parvovirus in dogs
Abstract
BACKGROUND: Dogs infected with canine parvovirus (CPV) have compromised intestinal epithelial barrier integrity. Production of D-lactate by enteric bacteria may directly reflect disease severity or contribute to metabolic acid-base status in these dogs. HYPOTHESIS: Serum D-lactate concentration will be increased in CPV dogs compared to healthy controls and correlate with markers of disease severity and acid-base status. ANIMALS: Dogs with CPV undergoing treatment (n = 40) and healthy control dogs (n = 9). METHODS: Prospective observational study. Dogs with CPV had a baseline and daily CBC, venous blood gas with serum electrolyte concentrations, composite clinical severity score, and serum D-lactate concentration performed. A single serum D-lactate measurement was obtained from healthy control dogs. RESULTS: The CPV dogs had a higher D-lactate concentration (mean ± SD) of 469 ± 173 μM compared to controls, 306 ± 45 μM (P < .001). There was no difference in baseline D-lactate concentrations for CPV survivors (474 ± 28 μM), versus nonsurvivors (424 ± 116 μM; P = .70). D-lactate concentration decreased over the first 4 days of treatment (-9.6 μM/d; P = .46). Dogs hospitalized for <4 days had lower baseline D-lactate concentrations compared to those hospitalized ≥4 days (400 ± 178 μM versus 520 ± 152 μM; P = .03). No sustained correlation over time between serum D-lactate concentration and clinical severity score or recorded acid-base results. CONCLUSIONS AND CLINICAL IMPORTANCE: Serum D-lactate concentrations are higher in dogs with CPV compared to healthy controls but do not appear to be clinically relevant. No relationship identified between serum D-lactate concentrations and markers of CPV disease severity, acid-base status, or outcome.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31919893/