Peer-reviewed veterinary case report
Vitamin D levels in dogs with high blood calcium explained
By Gerber, B et al.·Published in Veterinary research communications·2004·Clinic for Small Animal Internal Medicine·View original on PubMed →
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Original publication title: Serum levels of 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol in dogs with hypercalcaemia.
- Species:
- dog
Plain-English summary
A group of dogs with high calcium levels (hypercalcaemia) were tested to see how their vitamin D levels compared to healthy dogs. The dogs had various conditions, including lymphoma, primary hyperparathyroidism, and chronic kidney failure. The results showed that the vitamin D levels were lower in dogs with these health issues compared to healthy dogs, but there was no clear pattern linking the vitamin D levels to the specific causes of hypercalcaemia. This means that vitamin D levels alone can't help predict why a dog has high calcium levels.
People also search for: dog high calcium levels treatment · dog lymphoma symptoms · chronic kidney failure in dogs
Abstract
1,25-Dihydroxycholecalciferol (1,25-(OH)2-D3) and 25-hydroxycholecalciferol (25-OH-D3) were measured among dogs with hypercalcaemia (total serum calcium > 3.01 mmol/L) due to various causes. All values were compared to those of healthy control dogs. Serum 1,25-(OH)]2-D3 was measured by a radioimmunoassay test and serum 25-OH-D3 was measured by a protein binding assay. 1,25-(OH)2-D3 ranged from 26 to 332 pmol/L (median 110.0) in dogs with lymphoma (n = 12); from 61 to 398 pmol/L (median 248.0) in dogs with primary hyperparathyreoidism (n = 5); from 28 to 310 pmol/L (median 88.5) in dogs with chronic renal failure (n = 10); and from 60 to 239 pmol/L (median 157.5) in control dogs (n = 24). There was no significant difference in 1,25-(OH)2-D3 among dogs with different causes of hypercalcaemia. 25-OH-D3 ranged from 64 to 291 nmol/L (median 101.5) in dogs with lymphoma; from 66 to 298 nmol/L (median 91.0) in dogs with primary hyperparathyreoidism; from 35 to 184 nmol/L (median 67.0) in dogs with chronic renal failure; and from 48 to 350 nmol/L (median 306.5) in control dogs. 25-OH-D3 was significantly lower in dogs with lymphoma, primary hyperparathyroidism and chronic renal failure than in control dogs. 1,25-(OH)2-D3 and 25-OH-D3 are not predictable in dogs with hypercalcaemia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15609867/