Peer-reviewed veterinary case report
Neopterin blood levels in female dogs with malignant mammary tumors
By Szczubiał, M. et al.·Published in Veterinary and Comparative Oncology·2012·Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine University of Life Sciences Lublin Poland·View original on Crossref →
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Original publication title: Serum neopterin levels in female dogs with malignant mammary tumours
- Species:
- dog
Plain-English summary
A group of 50 female dogs with malignant mammary tumors underwent surgery to remove the tumors. Researchers measured a substance called neopterin in their blood, which can indicate how well the immune system is working. They found that the neopterin levels were lower in dogs with certain types of tumors compared to healthy dogs, suggesting that these dogs might have a weakened immune response. This information could help veterinarians understand more about how these tumors affect dogs and guide future treatments, but more research is needed to confirm these findings.
People also search for: female dog mammary tumor treatment · dog cancer immune system · neopterin levels in dogs
Abstract
AbstractIn this study, we have determined serum neopterin levels in female dogs with primary malignant mammary tumours. The study involved 50 female dogs which had a malignant mammary tumours removed surgically (32 animals with carcinoma, 12 animals with sarcoma and 6 animals with carcinosarcoma) and 10 clinically healthy female dogs. Serum neopterin levels were determined using a commercial ELISA kit. The mean neopterin levels were lower in the malignant tumour groups than in healthy animals but differences were statistically significant only in carcinoma and sarcoma groups. The decrease of neopterin levels in animals with malignant mammary tumours may suggest their decreased cellular immunity. Moreover, it might indicate that decreased activity of cellular mechanisms of the anti‐neoplastic response is one of the factors associated with the development and course of malignant mammary tumours in female dogs; however, further studies are necessary.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/j.1476-5829.2012.00347.x