Peer-reviewed veterinary case report
Blood test levels linked to malignant mammary tumors in dogs
By Tascene, N et al.·Published in Veterinary and comparative oncology·2012·Department of Biochemistry·View original on PubMed →
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Original publication title: Serum neopterin, sialic acid and nitric oxide levels in dogs with malignant mammary tumours.
- Species:
- dog
Plain-English summary
A group of dogs with malignant mammary tumors had higher levels of certain substances in their blood compared to healthy dogs. Specifically, the levels of nitric oxide and sialic acid were significantly elevated in the dogs with tumors, which could help in diagnosing the severity of the cancer. However, the levels of neopterin did not show a significant difference between the two groups. Understanding these changes in blood chemistry could be important for early detection and treatment of mammary cancer in dogs.
People also search for: dog mammary tumor symptoms · elevated nitric oxide in dogs · dog cancer blood test results
Abstract
Mammary cancer is one of the leading causes of death in pet population. Early diagnosis and malignancy detection is important for prognosis. The levels of neopterin, sialic acid and nitric oxide in serum of dogs with malignant mammary tumours were evaluated to investigate the importance of these biochemical parameters for malign mammary tumour. Twelve healthy dogs and twenty dogs with malignant mammary tumours were used as research materials. Blood samples were collected from both groups for neopterin analysis by enzyme-linked immunosorbent assay, whereas nitric oxide and sialic acid were measured by modified nitrate reductase method and spectrophotometry, respectively. Tissue specimens were evaluated and defined as malignant tumours. Serum nitric oxide and sialic acid levels in dogs with mammary tumours were significantly higher than those in the healthy dogs. Serum neopterin levels were not found significantly different in dogs with mammary tumours compared to healthy dogs. Malignancy of canine mammary tumours are accompained by an elevation of nitric oxide and sialic acid levels.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22235796/