Peer-reviewed veterinary case report
Dog with severe high iron and ferritin from immune anemia
By Zersen, Kristin M et al.·Published in Veterinary clinical pathology·2022·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Severe hyperferremia and hyperferritinemia in a dog with precursor-directed immune-mediated anemia.
- Species:
- dog
Plain-English summary
A 4-year-old dog was brought to the vet because she was very tired and not eating for a day. Tests showed she had severe anemia (low red blood cell count) and extremely high levels of iron and ferritin in her blood. After further examination, the vet diagnosed her with a condition called precursor-directed immune-mediated anemia, which affects the production of red blood cells. Following treatment, her iron levels improved significantly, indicating that the high iron was related to her anemia.
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Abstract
A 4-year-old dog was evaluated at the Colorado State University Veterinary Teaching Hospital for lethargy and hyporexia of 24 hours duration. On presentation, she had a marked normocytic, normochromic, nonregenerative anemia (HCT 14%; RI 40-55). Her serum iron concentration (1651 μg/dL; RI 73-245) and serum ferritin concentration (1337 ng/mL; RI 89-489) were markedly elevated. Bone marrow aspirate and core biopsy were consistent with a diagnosis of precursor-directed immune-mediate anemia. To the authors' knowledge, these are the highest reported serum iron and ferritin concentrations in a patient with precursor-directed immune-mediate anemia. The iron concentration improved significantly after treatment, supporting the theory that the hyperferremia was due to hemolysis and ineffective erythropoiesis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35578377/