Peer-reviewed veterinary case report
Gene variant linked to aggressive malignant mammary tumors in female
By Canadas-Sousa, Ana et al.·Published in Veterinary pathology·2021·University of Porto·View original on PubMed →
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Original publication title: Single Nucleotide Polymorphism in Prolactin Gene Is Associated With Clinical Aggressiveness and Outcome of Canine Mammary Malignant Tumors.
- Species:
- dog
Plain-English summary
A study found that a specific genetic change in the prolactin gene (SNP rs23932236) is linked to more aggressive mammary tumors in female dogs. The research involved 206 dogs with mammary tumors, showing that those with this genetic variant had larger tumors and a higher chance of spreading to lymph nodes and blood vessels. Unfortunately, these dogs also had a shorter survival time, averaging 18.7 months compared to 22.7 months for those without the variant. This information could help veterinarians identify which tumors may be more aggressive and require more urgent treatment.
People also search for: dog mammary tumor treatment · canine breast cancer survival · aggressive dog tumors genetics
Abstract
Prolactin (PRL) is a key hormone involved in canine mammary development and tumorigenesis. In this study, the influence of a single nucleotide polymorphism (SNP) in the PRL gene (rs23932236) on the clinicopathological parameters and survival of dogs with canine mammary tumors (CMTs) was investigated. A total of 206 female dogs with spontaneous mammary tumors were enrolled in this study and circulating blood cells were genotyped. This specific SNP was associated with larger size (>3 cm diameter) for malignant tumors (= .036), tumors with infiltrative/invasive growth pattern (= .010), vascular invasion (= .006), and lymph node metastasis (= .004). Carriers of the variant allele had a shorter overall survival compared to the wild-type population with an overall survival of 18.7 months and 22.7 months, respectively (= .004). These findings suggest that SNP rs23932236 of canine PRL gene may be used as an indicator for the development of clinically aggressive forms of CMTs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34121513/